Towards Malaria 'Vaccine': Discovery Opens The Door To Malaria-prevention Therapies

The point is that until the mechanism is defined, it's very hard to fix dysfunctional systems. As in health v disease, so it is in smart v stupid.

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"Researchers at the RI-MUHC and McGill University, discovered that hemozoin, a crystal-like substance may be the missing link that explains why malaria leads to devastating inflammation and fever.

'Our results describe the mechanism by which the hemozoin activates the immune system, resulting in the production of inflammation mediators and in the high fever that we witness in malaria patients,' said study first-author Dr. Marina Tiemi Shio of the RI-MUHC.

Hemozoin is first ingested by 'cleaning' cells called macrophages, explained the researcher which leads to a chain reaction ending in the activation of the inflammasome: an important structure inside immune cells which lead to inflammation. Activation of the inflammasome produces the body's fever mediator, interleukin beta (IL-beta)."
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